Dimitriya Milusheva was born on March 12th in Pazardzhik. As a child, she attended ballet classes, swimming, and various theatrical circles in her hometown. From 2000 to 2002, she was part of the educational theater at Plovdiv University under the guidance of Hristo Tserovski.

In 2007, she graduated with a major in "Acting for Drama Theater" from Paisii Hilendarski University in Plovdiv, in the class of Prof. Elisaveta Sotirova with assistant Todor Dimitrov. As part of her studies, she portrayed the naive Rosette in "No Trifling with Love" directed by Hristo Tserovski, and Hippolyta in "A Midsummer Night's Dream" directed by Todor Dimitrov. She also played Rosaline in "Love's Labour's Lost" directed by Vyara Nacheva, and many other roles. In her diploma performances, she had the opportunity to immerse herself in the role of Ranevskaya in "The Cherry Orchard," directed by Todor Dimitrov.

From 2007 to 2010, she worked as an actress at the "Racho Stoyanov" Drama Theater in Gabrovo. Her first role on a professional stage was as Juliet in "Romeo and Juliet," directed by Nevena Miteva. In the Gabrovo Theater, she collaborated with two Romanian directors. In their productions, she portrayed the cunning and assertive Didina in "Carnival Story" by Karadzhale, directed by Mihai Lundjanu, and the young mistress in "Love Quadrangle" by Karine Hodikyan, directed by Hakob Kazandzhyan. She also performed in the non-verbal play "Tatul," directed by Nadya Asenova and Nevena Miteva, and participated with it in festivals in Iran and Egypt.

She has also participated in performances for children, including "The Forest Maiden" directed by Nadya Asenova, and "The Merry Traffic Light" directed by Nevena Miteva.

Dimitriya played the role of a young woman and a witch in the play "Enyovden" directed by Yavor Binev, in a joint production with the Lovech Theater. This production was presented in exchange programs in Kiev.

In 2008, she participated in an international theater project at Thara Theatre in London, where she played Lucretia in "The Rape of Lucretia" directed by Mukul Ahmed.

Since 2009, she has been an actress at the Shumen Theater, where she has performed in numerous plays for both adults and children. She played the daughter in "The Happy Family," directed by Kolyo Mihaylov, and participated in the production of "Two on a Seesaw," directed by Yosif Surchadzhiev.

She took on the role of a student in "Dr." directed by Boyko Bogdanov, and Nina in "An Angel Emerged from the Fog," directed by Milen Dimitrov. She also portrayed Sonya in "Life in Three Versions," directed by Margarita Macheva, and played Neda in "The Beginning of Misunderstanding," directed by Plamen Markov. She participated in the dance performance "Kukeri" directed by Stefaniya Georgieva.

In 2022, she appeared in the film "Alo" directed by Stefan Komandarev.